catalina Catalina Garcia at April 16, 2024 at 12:19am PDT

Exosomes have high research value and application prospects due to their proven properties and biological functions. At the same time, their scale-up production, functional modification, storage and transportation, and other issues limiting their application transformation are being continuously improved. Creative Biolabs has been focusing on exosome-related services and product supply for many years and is capable of advancing our customers' understanding of exosomes and their application exploration. Learn more: exosome applications

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catalina Catalina Garcia at April 16, 2024 at 12:17am PDT

Therapeutic antibodies, specifically refer to monoclonal antibodies, are bioactive antibodies with the ability to attack specific cells or proteins for the treatment of a wide variety of diseases, including cancers, immune disorders, and infections. Therapeutic antibodies have been flourishingly developing since the first therapeutic antibody, Muromonab-CD3, was approved by the Food and Administration (FDA) as an immunosuppressive agent in 1986. Learn more: non-IgG antibodies Discovery

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catalina Catalina Garcia at April 09, 2024 at 1:45am PDT

Macrophages are specialized cells that rapidly recognize, engulf, and destroy pathogens or apoptotic cells. One of the fundamental features of macrophages is their high plasticity, which allows them to respond to stimuli from the complex tissue microenvironment, by changing rapidly their functional profile through polarization. Macrophages reveal specific phenotypes and functions in response to different triggers. Depending on the types of stimuli, they can polarize to M1 (pro-inflammatory) or M2 (anti-inflammatory) macrophages. Learn more: macrophages cells

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catalina Catalina Garcia at April 09, 2024 at 1:40am PDT

The team at Creative Biolabs has extensive experience in the technical field of live biotherapeutics. We have the knowledge and expertise to provide high-quality products and services and provide a high level of consultation to our clients on their next-generation probiotics development projects. Our clients include the world's leading pharmaceutical and biotechnology companies, as well as academic researchers. Learn more: Faecal Microbiota Transplants

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catalina Catalina Garcia at April 09, 2024 at 1:35am PDT

Creative Biolabs provides various high-quality cationic liposome products for your research. Formulations containing different lipid compositions and cationic lipid species are listed below for the best benefit of your requirements. The default particle size of the liposome is 100nm. Fluorescent dyes, PEGylation, and particle size are also highly adjustable. Learn more: Cationic Liposome

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To characterize the pluripotency of iPSC, a class of defined tests can be used, and usually iPSC are characterized with the criteria applied to ES cells. Due to the differences between iPSC and ES cell expression patterns, their characteristics also not exactly the same. There are a variety of features assessed by characterization, such as cell and colony morphology, the expression of surface markers and other antigens, growth rate, the expression of pluripotency marker genes, enzyme levels, methylation statuses, as well as differentiation into somatic cell types in vitro and in vivo. Learn more: iPSC Characterization

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Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Learn more: Alzheimer's Disease Models

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Parkinson's disease is a degenerative disease of the nervous system caused by the loss of dopaminergic neurons. The source of this pathological change is still unclear, but studies have shown that Lewy bodies containing alpha-synuclein (αSyn) are the typical neuropathological hallmark of the disease, and almost all patients with Parkinson's disease have different degrees of amyloid deposition in the brain cells, which can directly poison cells and destroy neurotransmitter transmission. Learn more: Alpha-Synuclein Aggregation Assay

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Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Human monocyte, human alveolar, murine peritoneal cavity, murine bone marrow, murine lung, and murine adipose tissues are available for macrophage isolation and culture. Our seasoned scientists are pleased to share our expertise and experience with our global clients and facilitate their meaningful macrophage project development. Learn more: macrophage differentiation

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Idea: dspe lipid

catalina Catalina Garcia about 1 month ago

1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) is a water soluble derivative of phosphatidylethanolamine with (18:0) stearic acid acyl chains. It is used to prepare the intermediate 1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine (DSPE)-polyethylene glycol (PEG)-SPDP for the preparation of Lipid-PEG-CpG. Learn more: dspe lipid

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Creative Biolabs is a leading service provider that focuses on live biotherapeutics drug discovery services. We are committed and proud to be part of this rewarding challenge by offering its support to the novel next-generation probiotics (NGPs) development services and pre-clinical drug discovery for our clients. We are proud to partner with you on the journey of bringing novel Escherichia coli (E. coli)-based live biotherapeutics drugs to disease therapy in the clinic. Learn more: escherichia coli 0157

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Complement factor H (CFH) is an essential regulator for normal complement activity, which negatively inhibits the alternative pathway and complement amplification. CFH is a large plasma protein encoded by the CFH gene. Human CFH is a 155 kDa heavily glycoprotein composed of 20 complement control protein (CCP) domains (or short consensus repeats), each of which consists of around 60 amino acids with 2 disulfides (CysI-CysIII and CysII-CysIV). Learn more: Factor H Antibody

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Antibodies have become essential tools for research use due to their high specificity, high binding affinity, long half-lives, and low toxicity. High-quality hybridoma development services at Creative Biolabs have covered you for your ELISA, western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), flow cytometry (FACS), or other assay needs. A personalized and flexible solution will be designed and adapted to your needs. Learn more: Function-guaranteed Antibody

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Recombinant monoclonal antibody to Human CD20. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder and thus affects the lymphatic system.

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Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Learn more: in vitro model for alzheimer's disease

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Calcium channels are ion channels that have selective permeability to calcium ions. Calcium is a vital signaling molecule that can mediate muscle contraction, nerve transmission, and gene expression. Disruption of normal calcium channel function causes a variety of diseases, such as inherited calcium channel diseases including neurological diseases (X-linked night blindness) and hemiplegic migraine; musculoskeletal diseases such as hypokalemic periodic paralysis and malignant hyperthermia; and cardiovascular diseases, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia. Learn more: Voltage-gated calcium channels research reagents

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The diagnosis of CVDs begins with the history and physical examination of suspected patients. Then, an array of laboratory tests and imaging studies can be performed to confirm or exclude the diagnosis. Blood tests based on immunoassay platforms are used to detect the risk factors for CVDs. Learn more: cardiovascular diseases diagnostic development

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A novel coronavirus (SARS-CoV-2) has been shown to be highly contagious and to cause many severe respiratory diseases in humans. The virus is a type of coronaviruses that has a single-stranded RNA genome, which is responsible for encoding several key proteins. With the outbreak of SARS-CoV-2 in Wuhan, Hubei Province, China, a number of in-vitro diagnostics (IVD) kits have been developed by using various PCR-based technologies, such as rRT-PCR, for screening the virus emergence in different populations. rRT-PCR has been considered as a benchmark for detecting and quantifying RNA targets and is being broadly used in clinical diagnosis. In rRT-PCR assays, an oligonucleotide probe will be designed to bind with the key sequence of SARS-CoV-2. Meanwhile, the probe will cleave when the Taq polymerase is added into this detection system. The cleavage will be detected once the fluorescent signal being released. Learn more: rRT-PCR for SARS-CoV-2

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The cephalosporin was found firstly from the aerobic mold in the sea near a sewage outfall in Su Siccu, Cagliari harbor in Sardinia, by the Italian pharmacologist Giuseppe Brotzu in July 1945. Cephalosporins are used for the prophylaxis and treatment of infections caused by bacteria which is susceptible to this kind of antibiotic. The first-generation cephalosporin predominantly against Gram-positive bacteria, the second to the fourth generation have enhanced activity against Gram-negative bacteria that lead to the more spectral antibacterial capability of cephalosporins. The latest generation cephalosporin has a greater resistance to β-lactamases than the third-generation.

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